Effects of Selenium and Exendin-4 on Glucagon-Like Peptide-1 Receptor, IRS-1, and Raf-1 in the Liver of Diabetic Rats
Copyright policy )Effects of Selenium and Exendin-4 on Glucagon-Like Peptide-1 Receptor, IRS-1, and Raf-1 in the Liver of Diabetic Rats
Selenium and exendin-4 exert antidiabetic effects by unknown mechanisms. Herein, we investigated their effects on the expression of glucagon-like peptide-1 receptor (GLP-1R), insulin receptor substrate-1 (IRS-1), and Raf-1 in the livers of rats with streptozotocin-induced diabetes. Diabetic rats were injected intraperitoneally with exendin-4 (0.03 μg/kg body weight) twice daily or treated with 5 ppm selenium as sodium selenite in drinking water for 4 weeks. Both selenium and exendin-4 reduced the hyperglycemia in diabetic rats. Induction of diabetes mellitus resulted in decreased level of GLP-1R and increased levels of IRS-1 and Raf-1 in the liver. Treatment of diabetic rats with selenium or exendin-4 resulted in increased level of GLP-1R and decreased levels of IRS-1 and Raf-1 in the liver, compared with the levels in diabetic rats. Therefore, the antidiabetic actions of selenium and exendin-4 involve their effects on GLP-1R, IRS-1, and Raf-1 levels in the liver.
- Alexandria University Egypt
- Beirut Arab University Lebanon
- American University of Beirut Lebanon
Blood Glucose, Male, Blotting, Western, MAP Kinase Kinase Kinases, Glucagon-Like Peptide-1 Receptor, Diabetes Mellitus, Experimental, Rats, Proto-Oncogene Proteins c-raf, Rats, Sprague-Dawley, Selenium, Sodium Selenite, Liver, Insulin Receptor Substrate Proteins, Receptors, Glucagon, Animals, Exenatide, Hypoglycemic Agents, Insulin, RNA, Messenger, Peptides
Blood Glucose, Male, Blotting, Western, MAP Kinase Kinase Kinases, Glucagon-Like Peptide-1 Receptor, Diabetes Mellitus, Experimental, Rats, Proto-Oncogene Proteins c-raf, Rats, Sprague-Dawley, Selenium, Sodium Selenite, Liver, Insulin Receptor Substrate Proteins, Receptors, Glucagon, Animals, Exenatide, Hypoglycemic Agents, Insulin, RNA, Messenger, Peptides
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