Neurokinin-1 receptors are decreased in major depressive disorder
Copyright policy )Neurokinin-1 receptors are decreased in major depressive disorder
Treatment with an antagonist at the neurokinin-1 (NK-1) receptor may alleviate depression, however the brain region(s) in which the NK-1 receptor antagonist exerts its therapeutic effect is unknown. [125I]BH-Substance P was used to measure NK-1 receptors postmortem in cytoarchitectonically defined areas of rostral orbitofrontal cortex (Brodmann's area 47) of subjects with major depressive disorder (n = 12, six females) and psychiatrically normal subjects (n = 11, five females). Six subjects with depression died by suicide. Subjects with depression showed decreased binding to NK-1 receptors across all cortical layers (p = 0.024). The pathophysiology of depression, and the reported therapeutic benefit of NK-1 receptor antagonists, may thus involve NK-1 receptors in prefrontal cortex.
- Child Mind Institute United States
- MIND Institute United States
- University of Mississippi United States
- University of Florida United States
- Mississippi Institutions of Higher Learning United States
Adult, Aged, 80 and over, Brain Chemistry, Male, Neurons, Depressive Disorder, Major, Binding Sites, Age Factors, Down-Regulation, Prefrontal Cortex, Middle Aged, Receptors, Neurokinin-1, Substance P, Binding, Competitive, Radioligand Assay, Suicide, Neurokinin-1 Receptor Antagonists, Humans, Female, Aged
Adult, Aged, 80 and over, Brain Chemistry, Male, Neurons, Depressive Disorder, Major, Binding Sites, Age Factors, Down-Regulation, Prefrontal Cortex, Middle Aged, Receptors, Neurokinin-1, Substance P, Binding, Competitive, Radioligand Assay, Suicide, Neurokinin-1 Receptor Antagonists, Humans, Female, Aged
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