Journal of Neurophysiology

Article . 2022 . Peer-reviewed

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Journal of Neurophysiology

Article . 2022

Data sources: Europe PubMed Central

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Modulation of in vitro epileptiform activity by optogenetic stimulation of parvalbumin-positive interneurons

descriptionPublicationkeyboard_double_arrow_right Article 01 Oct 2022 English Publisher:American Physiological SocietyJournal:Journal of Neurophysiology, volume 128, pages 837-846 (issn: 0022-3077, eissn: 1522-1598,

Authors: Siyan Wang; Cristen Kfoury; Alexis Marion; Maxime Lévesque; Massimo Avoli;

doi: 10.1152/jn.00192.2022

pmid: 36043700

Modulation of in vitro epileptiform activity by optogenetic stimulation of parvalbumin-positive interneurons

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Abstract

Previous studies have identified contradictory roles of PV-interneurons in ictogenesis and the link between theta oscillations and epileptiform activity remains unexplored. Here, we investigated in vitro the effect of PV-interneuron optogenetic stimulation under 4AP in temporal lobe regions obtained from PV-ChR2 transgenic mice. Under theta (8 Hz) optogenetic stimulation and 4AP application, interictal spikes and low-voltage fast onset ictal discharges were triggered, suggesting that the activation of PV-interneurons favors synchronization and ictogenesis.

Related Organizations

McGill University
Canada
Montreal Neurological Institute and Hospital
Canada

Keywords

Optogenetics, Mice, Parvalbumins, Opsins, Interneurons, Animals, Mice, Transgenic, 4-Aminopyridine, gamma-Aminobutyric Acid

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Modulation of in vitro epileptiform activity by optogenetic stimulation of parvalbumin-positive interneurons

Modulation of in vitro epileptiform activity by optogenetic stimulation of parvalbumin-positive interneurons

6 Research products, page 1 of 1

IL-6 Mediated Degeneration of Forebrain GABAergic Interneurons and Cognitive Impairment in Aged Mice through Activation of Neuronal NADPH Oxidase

Development of Perineuronal Nets during Ontogeny Correlates with Sensorimotor Vocal Learning in Canaries

Parvalbumin-Interneuron Output Synapses Show Spike-Timing-Dependent Plasticity that Contributes to Auditory Map Remodeling

Altered excitatory and decreased inhibitory transmission in the prefrontal cortex of male mice with early developmental disruption to the ventral hippocampus

Does schizophrenia arise from oxidative dysregulation of parvalbumin-interneurons in the developing cortex?

Autophagy in parvalbumin interneurons is required for inhibitory transmission and memory via regulation of synaptic proteostasis