Gait alterations in healthy carriers of the LRRK2 G2019S mutation
Copyright policy )Gait alterations in healthy carriers of the LRRK2 G2019S mutation
AbstractTo test for an association between the LRRK2‐G2019S mutation and gait, we studied 52 first‐degree relatives of patients with Parkinson's disease (PD) who carry this mutation. An accelerometer quantified gait during usual‐walking, fast‐walking, and dual‐tasking. Noncarriers (n = 27) and carriers (n = 25) were similar with respect to age, gender, height, and gait speed during all conditions. During dual‐tasking and fast‐walking, gait variability and the amplitude of the dominant peak of the accelerometer signal were significantly altered among the carriers. These findings support the possibility of previously unidentified, presymptomatic motor changes among relatives who have an increased risk of developing PD. Ann Neurol 2010
- Tel Aviv University Israel
- Tel Aviv Sourasky Medical Center Israel
- Harvard University United States
Gait Ataxia, Genetic Markers, Heterozygote, Risk Factors, Mutation, Humans, Genetic Predisposition to Disease, Parkinson Disease, Protein Serine-Threonine Kinases, Leucine-Rich Repeat Serine-Threonine Protein Kinase-2
Gait Ataxia, Genetic Markers, Heterozygote, Risk Factors, Mutation, Humans, Genetic Predisposition to Disease, Parkinson Disease, Protein Serine-Threonine Kinases, Leucine-Rich Repeat Serine-Threonine Protein Kinase-2
citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).140 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Top 1% influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Top 10% impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 1%
Citations provided by BIP!Popularity provided by BIP!