Maternal human leukocyte antigen-G (HLA-G) genetic variants associate with in utero mother-to-child transmission of HIV-1 in Black South Africans
Copyright policy )Maternal human leukocyte antigen-G (HLA-G) genetic variants associate with in utero mother-to-child transmission of HIV-1 in Black South Africans
A 14-bp insertion/deletion (indel) within the 3' untranslated region (3'UTR) that affects HLA-G expression has been associated with HIV-1 mother-to-child transmission (MTCT). However, other 3'UTR single nucleotide polymorphisms (SNPs) that influence HLA-G mRNA stability have been described but not analysed in the context of MTCT, and little is known about the role of HLA-G alleles. We examined HLA-G alleles and 3'UTR SNPs, including the 14-bp indel, in 216 mother-infant pairs from Johannesburg, South Africa. Mother-infant pairs were classified as HIV-1 non-transmitting (NT, n=144) or HIV-1 transmitting (TR, n=72) with either intrapartum (IP, n=29) or in utero (IU, n=19) infected infants. We found HLA-G allele, G(∗)01:01:02 (in strong linkage disequilibrium with the 14-bp insertion) and +3187G SNP were significantly over-represented in IU-TR mothers compared to NT mothers (P=0.036, OR=2.26; P=0.011, OR=2.96, respectively). These findings suggest that maternal HLA-G alleles and/or SNPs that might alter expression of HLA-G potentially influence IU HIV-1 MTCT.
- King’s University United States
- University of the Witwatersrand South Africa
- National Institute for Communicable Diseases South Africa
- Columbia University United States
- National Health Laboratory Service South Africa
Adult, HLA-G Antigens, Base Sequence, Molecular Sequence Data, Black People, Infant, Mothers, HIV Infections, Polymorphism, Single Nucleotide, Infectious Disease Transmission, Vertical, Linkage Disequilibrium, South Africa, Gene Frequency, Haplotypes, INDEL Mutation, Case-Control Studies, HIV-1, Humans, Female, 3' Untranslated Regions
Adult, HLA-G Antigens, Base Sequence, Molecular Sequence Data, Black People, Infant, Mothers, HIV Infections, Polymorphism, Single Nucleotide, Infectious Disease Transmission, Vertical, Linkage Disequilibrium, South Africa, Gene Frequency, Haplotypes, INDEL Mutation, Case-Control Studies, HIV-1, Humans, Female, 3' Untranslated Regions
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