The EGF-TM7 family: a postgenomic view
Copyright policy )The EGF-TM7 family: a postgenomic view
With the human and mouse genome projects now completed, the receptor repertoire of mammalian cells has finally been elucidated. The EGF-TM7 receptors are a family of class B seven-span transmembrane (TM7) receptors predominantly expressed by cells of the immune system. Within the large TM7 superfamily, the molecular structure and ligand-binding properties of EGF-TM7 receptors are unique. Derived from the processing of a single polypeptide, they are expressed at the cell surface as heterodimers consisting of a large extracellular region associated with a TM7 moiety. Through a variable number of N-terminal epidermal growth factor (EGF)-like domains, EGF-TM7 receptors interact with cellular ligands such as CD55 and chondroitin sulfate. Recent in vivo studies demonstrate a role of the EGF-TM7 receptor CD97 in leukocyte migration. The different number of EGF-TM7 genes in man compared with mice, the chimeric nature of EMR2 and the inactivation of human EMR4 point toward a still-evolving receptor family. Here we discuss the currently available information on this intriguing receptor family.
- University of Oxford United Kingdom
- Amsterdam UMC, location AMC Netherlands
- University of Amsterdam Netherlands
Models, Molecular, Primates, Epidermal Growth Factor, Sequence Homology, Amino Acid, Protein Conformation, Molecular Sequence Data, Membrane Proteins, Muscle, Smooth, Protein Structure, Tertiary, Receptors, G-Protein-Coupled, Evolution, Molecular, Mice, Cell Movement, GTP-Binding Proteins, Multigene Family, Animals, Humans, Myeloid Cells, Amino Acid Sequence, Sequence Alignment
Models, Molecular, Primates, Epidermal Growth Factor, Sequence Homology, Amino Acid, Protein Conformation, Molecular Sequence Data, Membrane Proteins, Muscle, Smooth, Protein Structure, Tertiary, Receptors, G-Protein-Coupled, Evolution, Molecular, Mice, Cell Movement, GTP-Binding Proteins, Multigene Family, Animals, Humans, Myeloid Cells, Amino Acid Sequence, Sequence Alignment
citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).119 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Top 10% influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Top 10% impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 1%
Citations provided by BIP!Popularity provided by BIP!