Disc1 is mutated in the 129S6/SvEv strain and modulates working memory in mice
Copyright policy )Disc1 is mutated in the 129S6/SvEv strain and modulates working memory in mice
Disrupted-In-Schizophrenia ( DISC1 ) is a leading candidate schizophrenia susceptibility gene. Here, we describe a deletion variant in mDisc1 specific to the 129S6/SvEv strain that introduces a termination codon at exon 7, abolishes production of the full-length protein, and impairs working memory performance when transferred to the C57BL/6J genetic background. Our findings provide insights into how DISC1 variation contributes to schizophrenia susceptibility in humans and the behavioral divergence between 129S6/SvEv and C57BL/6J mouse strains and have implications for modeling psychiatric diseases in mice.
- Rockefeller University United States
- ROCKEFELLER UNIVERSITY
- Rockefeller University United States
- Columbia University Medical Center United States
Male, DNA, Complementary, Base Sequence, Molecular Sequence Data, Brain, Mice, Inbred Strains, Nerve Tissue Proteins, Exons, Mice, Mutant Strains, Mice, Inbred C57BL, Disease Models, Animal, Mice, Memory, Mutation, Codon, Terminator, Schizophrenia, Animals, Humans, Female, Amino Acid Sequence
Male, DNA, Complementary, Base Sequence, Molecular Sequence Data, Brain, Mice, Inbred Strains, Nerve Tissue Proteins, Exons, Mice, Mutant Strains, Mice, Inbred C57BL, Disease Models, Animal, Mice, Memory, Mutation, Codon, Terminator, Schizophrenia, Animals, Humans, Female, Amino Acid Sequence
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