Imaging Characteristics in <i>ALK</i> Fusion-Positive Lung Adenocarcinomas by Using HRCT
Copyright policy )Imaging Characteristics in <i>ALK</i> Fusion-Positive Lung Adenocarcinomas by Using HRCT
We aimed to identify high-resolution computed tomography (HRCT) features useful to distinguish the anaplastic lymphoma kinase gene (ALK) fusion-positive and negative lung adenocarcinomas.We included 236 surgically resected adenocarcinoma lesions, which included 27 consecutive ALK fusion-positive (AP) lesions, 115 epidermal growth factor receptor mutation-positive lesions, and 94 double-negative lesions. HRCT parameters including size, air bronchograms, pleural indentation, spiculation, and tumor disappearance rate (TDR) were compared. In addition, prevalence of small lesions (≤20 mm) and solid lesions (TDR ≤20%) were compared.AP lesions were significantly smaller and had lower TDR (%) than ALK fusion-negative (AN) lesions (tumor diameter: 20.7 mm ± 14.1 mm vs. 27.4 mm ± 13.8 mm, respectively, p 20 mm (n = 7, 25.9%) showed a solid pattern. Among all small lesions, AP lesions had lower TDR and more frequent spiculation than AN lesions (p 20 mm lesions may be ALK fusion-negative.
Adult, Aged, 80 and over, Male, Lung Neoplasms, Receptor Protein-Tyrosine Kinases, Adenocarcinoma of Lung, Adenocarcinoma, Middle Aged, ErbB Receptors, Phenotype, Predictive Value of Tests, Multidetector Computed Tomography, Mutation, Biomarkers, Tumor, Humans, Anaplastic Lymphoma Kinase, Female, Genetic Predisposition to Disease, Gene Fusion, Aged
Adult, Aged, 80 and over, Male, Lung Neoplasms, Receptor Protein-Tyrosine Kinases, Adenocarcinoma of Lung, Adenocarcinoma, Middle Aged, ErbB Receptors, Phenotype, Predictive Value of Tests, Multidetector Computed Tomography, Mutation, Biomarkers, Tumor, Humans, Anaplastic Lymphoma Kinase, Female, Genetic Predisposition to Disease, Gene Fusion, Aged
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