FRIP, a Hematopoietic Cell-Specific rasGAP-Interacting Protein Phosphorylated in Response to Cytokine Stimulation
Copyright policy )FRIP, a Hematopoietic Cell-Specific rasGAP-Interacting Protein Phosphorylated in Response to Cytokine Stimulation
The human IL-4 receptor contains a sequence (the 14R motif) centered on Y497 that, when phosphorylated, interacts with phosphotyrosine-binding (PTB) domain proteins. Here, we describe a PTB domain protein, FRIP, that is phosphorylated in response to cytokine stimulation. FRIP is related to the rasGAP-associated protein p62dok and is bound by the N-terminal SH2 domain of rasGAP. The frip gene maps to the hairless (hr) locus on mouse chromosome 14. hr/hr mice exhibit lymphadenopathy, and their lymph node T cells proliferate more vigorously to anti-CD3 with IL-4 or IL-2 stimulation than +/hr T cells. FRIP expression is significantly reduced in T cells from hr/hr mice. FRIP may negatively regulate proliferation by acting as an adapter molecule between rasGAP and receptor complexes.
- National Institutes of Health United States
- National Institute of Allergy and Infectious Diseases United States
- National Institute of Health Pakistan
CD4-Positive T-Lymphocytes, Male, DNA, Complementary, Immunology, Molecular Sequence Data, Cell Line, Mice, Immunology and Allergy, Animals, Humans, Amino Acid Sequence, Cells, Cultured, Cell Line, Transformed, Base Sequence, GTPase-Activating Proteins, Chromosome Mapping, DNA-Binding Proteins, Mice, Inbred C57BL, Infectious Diseases, Interleukin-2, Female, Interleukin-3, Interleukin-4
CD4-Positive T-Lymphocytes, Male, DNA, Complementary, Immunology, Molecular Sequence Data, Cell Line, Mice, Immunology and Allergy, Animals, Humans, Amino Acid Sequence, Cells, Cultured, Cell Line, Transformed, Base Sequence, GTPase-Activating Proteins, Chromosome Mapping, DNA-Binding Proteins, Mice, Inbred C57BL, Infectious Diseases, Interleukin-2, Female, Interleukin-3, Interleukin-4
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