Evidence for a Direct Link between Glutathione Biosynthesis and Stress Defense Gene Expression in Arabidopsis[W]
Copyright policy )Evidence for a Direct Link between Glutathione Biosynthesis and Stress Defense Gene Expression in Arabidopsis[W]
AbstractThe mutant regulator of APX2 1-1 (rax1-1) was identified in Arabidopsis thaliana that constitutively expressed normally photooxidative stress-inducible ASCORBATE PEROXIDASE2 (APX2) and had ≥50% lowered foliar glutathione levels. Mapping revealed that rax1-1 is an allele of γ-GLUTAMYLCYSTEINE SYNTHETASE 1 (GSH1), which encodes chloroplastic γ-glutamylcysteine synthetase, the controlling step of glutathione biosynthesis. By comparison of rax1-1 with the GSH1 mutant cadmium hypersensitive 2, the expression of 32 stress-responsive genes was shown to be responsive to changed glutathione metabolism. Under photo-oxidative stress conditions, the expression of a wider set of defense-related genes was altered in the mutants. In wild-type plants, glutathione metabolism may play a key role in determining the degree of expression of defense genes controlled by several signaling pathways both before and during stress. This control may reflect the physiological state of the plant at the time of the onset of an environmental challenge and suggests that changes in glutathione metabolism may be one means of integrating the function of several signaling pathways.
- National Research Council Italy
- Biotechnology and Biological Sciences Research Council United Kingdom
- Spanish National Research Council Spain
- John Innes Centre United Kingdom
- Norwich University United States
defence, DNA, Complementary, Light, Glutamate-Cysteine Ligase, Molecular Sequence Data, Arabidopsis, Down-Regulation, Genes, Plant, Gene Expression Regulation, Plant, Sequence Homology, Nucleic Acid, Heat-Shock Proteins, Sequence Homology, Amino Acid, Arabidopsis Proteins, Bacterial Infections, Glutathione, Oxidative Stress, Peroxidases, Mutagenesis, Mutation, gene expression, microarray, Photic Stimulation, Signal Transduction
defence, DNA, Complementary, Light, Glutamate-Cysteine Ligase, Molecular Sequence Data, Arabidopsis, Down-Regulation, Genes, Plant, Gene Expression Regulation, Plant, Sequence Homology, Nucleic Acid, Heat-Shock Proteins, Sequence Homology, Amino Acid, Arabidopsis Proteins, Bacterial Infections, Glutathione, Oxidative Stress, Peroxidases, Mutagenesis, Mutation, gene expression, microarray, Photic Stimulation, Signal Transduction
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