Transcriptional regulation via TF-modifying enzymes: an integrative model-based analysis
Copyright policy )Transcriptional regulation via TF-modifying enzymes: an integrative model-based analysis
Transcription factor activity is largely regulated through post-translational modification. Here, we report the first integrative model of transcription that includes both interactions between transcription factors and promoters, and between transcription factors and modifying enzymes. Simulations indicate that our method is robust against noise. We validated our tool on a well-studied stress response network in yeast and on a STAT1-mediated regulatory network in human B cells. Our work represents a significant step toward a comprehensive model of gene transcription.
- University of Pennsylvania United States
- UNIVERSITY OF PENNSYLVANIA
- The Wharton School, University of Pennsylvania United States
- University of Pennsylvania, The Wharton School United States
B-Lymphocytes, Saccharomyces cerevisiae Proteins, Models, Genetic, Transcription, Genetic, Saccharomyces cerevisiae, DNA-Binding Proteins, STAT1 Transcription Factor, Gene Expression Regulation, Methods Online, Humans, Computer Simulation, Gene Regulatory Networks, Promoter Regions, Genetic, Protein Kinases, Software, Signal Transduction, Transcription Factors
B-Lymphocytes, Saccharomyces cerevisiae Proteins, Models, Genetic, Transcription, Genetic, Saccharomyces cerevisiae, DNA-Binding Proteins, STAT1 Transcription Factor, Gene Expression Regulation, Methods Online, Humans, Computer Simulation, Gene Regulatory Networks, Promoter Regions, Genetic, Protein Kinases, Software, Signal Transduction, Transcription Factors
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