Sox1 directly regulates the gamma -crystallin genes and is essential for lens development in mice
Copyright policy )Sox1 directly regulates the gamma -crystallin genes and is essential for lens development in mice
gamma-Crystallins are major structural components of the lens fiber cells in amphibians and mammals. Many dominant inherited cataracts in humans and mice have been shown to map within the gamma-crystallin gene cluster. Several transcription factors, including PAX6 and SOX proteins, have been suggested as candidates for crystallin gene regulation. Here we show that the targeted deletion of Sox1 in mice causes microphthalmia and cataract. Mutant lens fiber cells fail to elongate, probably as a result of an almost complete absence of gamma-crystallins. It appears that the direct interaction of the SOX1 protein with a promoter element conserved in all gamma-crystallin genes is responsible for their expression.
- Medical Research Council United Kingdom
- Osaka University Japan
- Imperial College Healthcare NHS Trust United Kingdom
- Hammersmith Hospital United Kingdom
Binding Sites, High Mobility Group Proteins, Gene Expression, Nuclear Proteins, Mice, Inbred Strains, Crystallins, Immunohistochemistry, Recombinant Proteins, DNA-Binding Proteins, Mice, Inbred C57BL, Mice, Gene Expression Regulation, Genes, HMGB Proteins, Multigene Family, Lens, Crystalline, Mutagenesis, Site-Directed, Animals, Promoter Regions, Genetic, Protein Binding
Binding Sites, High Mobility Group Proteins, Gene Expression, Nuclear Proteins, Mice, Inbred Strains, Crystallins, Immunohistochemistry, Recombinant Proteins, DNA-Binding Proteins, Mice, Inbred C57BL, Mice, Gene Expression Regulation, Genes, HMGB Proteins, Multigene Family, Lens, Crystalline, Mutagenesis, Site-Directed, Animals, Promoter Regions, Genetic, Protein Binding
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