The Significant Role of a Functional Polymorphism in the NF-κB1 Gene in Breast Cancer: Evidence from an Iranian Cohort
Copyright policy )The Significant Role of a Functional Polymorphism in the NF-κB1 Gene in Breast Cancer: Evidence from an Iranian Cohort
Aims: Breast cancer (BC) is one of the most common cancers among women. The influence of genetic variations on BC risk has been thus far assessed via genome-wide association studies. NF-κB has been recognized as a major player in BC progression. In this study, the association between rs28362491 and BC was evaluated in a population from northeastern Iran. Materials & methods: This study was conducted on 476 patients with BC and 524 healthy controls. The genotyping method used was an amplification-refractory mutation system. Results: The INS/DEL genotype conferred a statistically significant increased risk in patients in comparison with controls. Additionally, in the recessive model, INS/INS + INS/DEL versus DEL/DEL was statistically significant (OR = 0.34; 95% CI: 0.12-0.96; p = 0.042). Conclusion: This study found that rs28362491, as a susceptibility genetic factor, may affect BC risk in the Iranian population.
- Pharmaceutical Sciences Research Center Iran (Islamic Republic of)
- Shahid Sadoughi University of Medical Sciences and Health Services Iran (Islamic Republic of)
- Shiraz University of Medical Sciences Iran (Islamic Republic of)
- Ferdowsi University of Mashhad Iran (Islamic Republic of)
- Mashhad University of Medical Sciences Iran (Islamic Republic of)
Adult, Polymorphism, Genetic, Genotype, NF-kappa B p50 Subunit, Breast Neoplasms, Iran, Middle Aged, Risk Assessment, Cohort Studies, Young Adult, Gene Frequency, Risk Factors, Population Surveillance, Humans, Genetic Predisposition to Disease, Disease Susceptibility, Alleles
Adult, Polymorphism, Genetic, Genotype, NF-kappa B p50 Subunit, Breast Neoplasms, Iran, Middle Aged, Risk Assessment, Cohort Studies, Young Adult, Gene Frequency, Risk Factors, Population Surveillance, Humans, Genetic Predisposition to Disease, Disease Susceptibility, Alleles
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