Polymorphisms in theARandPSAGenes as Markers of Susceptibility and Aggressiveness in Prostate Cancer
Copyright policy )Polymorphisms in theARandPSAGenes as Markers of Susceptibility and Aggressiveness in Prostate Cancer
The study of genes involved in androgen pathway can contribute to a better knowledge of prostate cancer. Our aim was to examine if polymorphisms in prostate-specific antigen (PSA) and androgen receptor (AR) genes were involved in prostate cancer risk and aggressiveness. Genotypes were determined by PCR-RFLP (PSA) or using a 377 ABI DNA Sequencer (AR). PSA(G/G) genotype (OR = 1.78, 95% CI = 1.06–2.99) and AR short CAG repeats (OR = 1.89, 95% CI = 1.21–2.96) increased risk for prostate cancer and were related with tumor aggressiveness. About 38.3% of tumors showed microsatellite instability. In conclusion, polymorphisms in these genes may be indicated as potential biomarkers for prostate cancer.
- Sao Paulo State University Brazil
- Universidade Estadual Paulista - UNESP Brazil
- Londrina State University Brazil
- Health Sciences Centre Canada
Male, Genotype, Polymerase Chain Reaction, Gene Frequency, Trinucleotide Repeats, Biomarkers, Tumor, Humans, Genetic Predisposition to Disease, Neoplasm Invasiveness, Gleason score, AR gene, Alleles, Aged, Polymorphism, Genetic, Prostate Cancer, Histopathological parameters, Prostatic Neoplasms, Sequence Analysis, DNA, Middle Aged, Prostate-Specific Antigen, PSA gene, Receptors, Androgen, Polymorphisms, Polymorphism, Restriction Fragment Length
Male, Genotype, Polymerase Chain Reaction, Gene Frequency, Trinucleotide Repeats, Biomarkers, Tumor, Humans, Genetic Predisposition to Disease, Neoplasm Invasiveness, Gleason score, AR gene, Alleles, Aged, Polymorphism, Genetic, Prostate Cancer, Histopathological parameters, Prostatic Neoplasms, Sequence Analysis, DNA, Middle Aged, Prostate-Specific Antigen, PSA gene, Receptors, Androgen, Polymorphisms, Polymorphism, Restriction Fragment Length
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