MOESM1 of ALS-linked TDP-43M337V knock-in mice exhibit splicing deregulation without neurodegeneration

descriptionPublicationkeyboard_double_arrow_right Other literature type 01 Jan 2020Publisher:figshare

Authors: Watanabe, Seiji; Oiwa, Kotaro; Murata, Yuri; Okiru Komine; Sobue, Akira; Fumito Endo; Eiki Takahashi; +1 Authors

doi: 10.6084/m9.figshare.11665335.v1 , 10.6084/m9.figshare.11665335

MOESM1 of ALS-linked TDP-43M337V knock-in mice exhibit splicing deregulation without neurodegeneration

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Abstract

Additional file 1. Material and methods. Figure S1. Direct sequencing of Tardbp gene exon 6 in heterozygous TDP-43M337V knock-in mice. Figure S2. Body weights were not affected in TDP-43M337V knock-in mice. Figure S3. Relative expression levels of Notch1 and Nek1 mRNAs were not altered in the brain of aged homozygous TDP-43M337V mice. Figure S4. Splicing was not altered in Eif4h or Poldip3, which are also regulated by TDP-43, in the brain of aged homozygous TDP-43M337V mouse brains. Figure S5. Gliosis was not observed in ventral horn of aged (700 days-old) homozygous TDP-43M337V mice. Figure S6. The number of Gems was not affected in ventral horn neurons of aged (700 days-old) homozygous TDP-43M337V mice.

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