Loss-of-function of the protein kinase C δ (PKCδ) causes a B-cell lymphoproliferative syndrome in humans
Copyright policy )Loss-of-function of the protein kinase C δ (PKCδ) causes a B-cell lymphoproliferative syndrome in humans
Key PointsMutations in PRKCD cause a syndrome characterized by chronic benign lymphadenopathy, positive autoantibodies, and NK dysfunction. PRKCD deficiency disrupts control of B-cell proliferation and apoptosis and affects NK-cell cytolytic activity.
- National Institute of Allergy and Infectious Diseases United States
- National Institute of Health Pakistan
- National Institutes of Health United States
- National Cancer Institute Malaysia
- University of Illinois at Chicago United States
Male, B-Lymphocytes, Epstein-Barr Virus Infections, Herpesvirus 4, Human, Autoimmune Lymphoproliferative Syndrome, Homozygote, Gene Expression, Apoptosis, Cell Line, Killer Cells, Natural, Mice, Gene Knockdown Techniques, Mutation, Animals, Cytokines, Humans, Lymph Nodes, Child, Lymphatic Diseases, Cell Proliferation
Male, B-Lymphocytes, Epstein-Barr Virus Infections, Herpesvirus 4, Human, Autoimmune Lymphoproliferative Syndrome, Homozygote, Gene Expression, Apoptosis, Cell Line, Killer Cells, Natural, Mice, Gene Knockdown Techniques, Mutation, Animals, Cytokines, Humans, Lymph Nodes, Child, Lymphatic Diseases, Cell Proliferation
citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).131 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Top 1% influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Top 10% impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 1%
Citations provided by BIP!Popularity provided by BIP!