The effect of a synergistic concentration of a Piper nigrum extract used in conjunction with pyrethrum upon gene expression in Drosophila melanogaster
Copyright policy )The effect of a synergistic concentration of a Piper nigrum extract used in conjunction with pyrethrum upon gene expression in Drosophila melanogaster
Abstract An ethyl acetate extract of Piper nigrum L. (Piperaceae) peppercorns was tested as a synergist for the botanical insecticide pyrethrum. A high synergist ratio of 11.6 against Drosophila melanogaster was obtained for the combination of pyrethrum supplemented with P. nigrum . The effect of this combination was investigated using cDNA microarray analysis of gene expression profiles in D. melanogaster . Treatment of D. melanogaster with pyrethrum alone resulted in a large number of differentially expressed genes, principally associated with stress responses. Seven genes were identified as being commonly expressed in D. melanogaster treated with at least two of the following treatments: P. nigrum, pyrethrum or P. nigrum plus pyrethrum. These are likely implicated in Drosophila defence responses to toxins.
- Health Canada Canada
- University of Ottawa Canada
Insecticides, Chrysanthemum cinerariifolium, Ethanol, Plant Extracts, Reverse Transcriptase Polymerase Chain Reaction, Gene Expression, Drug Synergism, Genes, Insect, Drosophila melanogaster, Animals, Female, Piper nigrum, Oligonucleotide Array Sequence Analysis
Insecticides, Chrysanthemum cinerariifolium, Ethanol, Plant Extracts, Reverse Transcriptase Polymerase Chain Reaction, Gene Expression, Drug Synergism, Genes, Insect, Drosophila melanogaster, Animals, Female, Piper nigrum, Oligonucleotide Array Sequence Analysis
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