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Interfering with Apoptosis: Ca 2+ -Binding Protein ALG-2 and Alzheimer's Disease Gene ALG-3
Copyright policy ) Vito P; LACANA E; D'ADAMIO, LUCIANO;
Interfering with Apoptosis: Ca 2+ -Binding Protein ALG-2 and Alzheimer's Disease Gene ALG-3
Two apoptosis-linked genes, named ALG-2 and ALG-3 , were identified by means of a functional selection strategy. ALG-2 codes for a Ca 2+ -binding protein required for T cell receptor-, Fas-, and glucocorticoid-induced cell death. ALG-3 , a partial complementary DNA that is homologous to the familial Alzheimer's disease gene STM2 , rescues a T cell hybridoma from T cell receptor- and Fas-induced apoptosis. These findings suggest that ALG-2 may mediate Ca 2+ -regulated signals along the death pathway and that cell death may play a role in Alzheimer's disease.
- National Institute of Allergy and Infectious Diseases United States
- National Institutes of Health United States
- National Institute of Health Pakistan
- University Federico II of Naples Italy
DNA, Complementary, Fas Ligand Protein, Hybridomas, Membrane Glycoproteins, Calcium-Binding Proteins, Molecular Sequence Data, Membrane Proteins, Apoptosis, Dexamethasone, Cell Line, Mice, Alkaloids, Alzheimer Disease, Dactinomycin, Animals, Interleukin-2, Calcium, Amino Acid Sequence, Cloning, Molecular, Apoptosis Regulatory Proteins
DNA, Complementary, Fas Ligand Protein, Hybridomas, Membrane Glycoproteins, Calcium-Binding Proteins, Molecular Sequence Data, Membrane Proteins, Apoptosis, Dexamethasone, Cell Line, Mice, Alkaloids, Alzheimer Disease, Dactinomycin, Animals, Interleukin-2, Calcium, Amino Acid Sequence, Cloning, Molecular, Apoptosis Regulatory Proteins
citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).510 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Top 10% influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Top 1% impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 0.1% views 32 downloads 33 - 32views33downloads
citations
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This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
Citations provided by BIP!popularityPopularity provided by BIP!
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
Popularity provided by BIP!influenceInfluence provided by BIP!
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
Influence provided by BIP!impulseImpulse provided by BIP!
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
Impulse provided by BIP!viewsViews provided by UsageCounts
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