An Xist-activating antisense RNA required for X-chromosome inactivation
Copyright policy )An Xist-activating antisense RNA required for X-chromosome inactivation
AbstractThe transcriptional imbalance due to the difference in the number of X chromosomes between male and female mammals is remedied through X-chromosome inactivation, the epigenetic transcriptional silencing of one of the two X chromosomes in females. The X-linked Xist long non-coding RNA functions as an X inactivation master regulator; Xist is selectively upregulated from the prospective inactive X chromosome and is required in cis for X inactivation. Here we discover an Xist antisense long non-coding RNA, XistAR (XistActivating RNA), which is encoded within exon 1 of the mouse Xist gene and is transcribed only from the inactive X chromosome. Selective truncation of XistAR, while sparing the overlapping Xist RNA, leads to a deficiency in Xist RNA expression in cis during the initiation of X inactivation. Thus, the Xist gene carries within its coding sequence an antisense RNA that drives Xist expression.
- University of Michigan–Flint United States
- Kindai University Japan
- University of Michigan–Ann Arbor United States
Male, Chromosome Mapping, Article, Cell Line, Mice, Inbred C57BL, X Chromosome Inactivation, Animals, Female, RNA, Antisense, RNA, Long Noncoding, In Situ Hybridization, Fluorescence
Male, Chromosome Mapping, Article, Cell Line, Mice, Inbred C57BL, X Chromosome Inactivation, Animals, Female, RNA, Antisense, RNA, Long Noncoding, In Situ Hybridization, Fluorescence
citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).33 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Top 10% influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Average impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 10%
Citations provided by BIP!Popularity provided by BIP!