The SNP276G>T polymorphism in the adiponectin (ACDC) gene is more strongly associated with insulin resistance and cardiovascular disease risk than SNP45T>G in nonobese/nondiabetic Korean men independent of abdominal adiposity and circulating plasma adiponectin
Copyright policy )The SNP276G>T polymorphism in the adiponectin (ACDC) gene is more strongly associated with insulin resistance and cardiovascular disease risk than SNP45T>G in nonobese/nondiabetic Korean men independent of abdominal adiposity and circulating plasma adiponectin
This study aimed to determine whether polymorphisms of the adiponectin (ACDC) gene independently contribute to insulin resistance (IR) and other cardiovascular disease (CVD) risk factors in nonobese, nondiabetic Korean men after adjusting for major environmental factors that influence IR. Among the 7 ACDC single-nucleotide polymorphisms (SNPs;C-11377G, T45G, G276T, H241P, Y111H, G90S, and R221S) prescreened in 48 subjects, we genotyped 333 subjects for SNP45 and SNP276, both of which showed an allele frequency of more than 2%. In Pearson correlation and multiple stepwise regression analyses, we found that waist circumference was the most important influencing factor (beta = .369, P T, rather than SNP45T>G, is more strongly associated (both directly and indirectly) than with several components of metabolic syndrome and CVD risk, including IR, triglyceride concentration, and low-density lipoprotein particle size, in nonobese, nondiabetic men.
- Yonsei University Korea (Republic of)
- Yonsei University Health System Korea (Republic of)
- Yonsei University Medical Library Korea (Republic of)
- Tufts University United States
Blood Glucose, Male, Adipose Tissue/anatomy & histology, Body Height/physiology, Fatty Acids, Nonesterified, Insulin Resistance/genetics*, Risk Factors, Malondialdehyde, Abdomen, Abdomen/anatomy & histology, Genetic/physiology*, Korea/epidemiology, Anthropometry, Fatty Acids, Middle Aged, Lipids, LDL/blood, Lipoproteins, LDL, C-Reactive Protein, Adipose Tissue, Cardiovascular Diseases, Abdomen/physiology, Adiponectin/blood, Adiponectin, Cardiovascular Diseases/genetics*, Adult, Lipid Peroxides, Nonesterified/blood, Adiponectin/genetics*, Genotype, Lipoproteins, 610, Lipid Peroxides/metabolism, Humans, Particle Size, Polymorphism, Korea, Blood Glucose/metabolism, Lipids/blood, C-Reactive Protein/metabolism, Body Weight, Adipose Tissue/physiology*, Cardiovascular Diseases/epidemiology*, Body Height, Body Weight/physiology, Malondialdehyde/metabolism, Insulin Resistance
Blood Glucose, Male, Adipose Tissue/anatomy & histology, Body Height/physiology, Fatty Acids, Nonesterified, Insulin Resistance/genetics*, Risk Factors, Malondialdehyde, Abdomen, Abdomen/anatomy & histology, Genetic/physiology*, Korea/epidemiology, Anthropometry, Fatty Acids, Middle Aged, Lipids, LDL/blood, Lipoproteins, LDL, C-Reactive Protein, Adipose Tissue, Cardiovascular Diseases, Abdomen/physiology, Adiponectin/blood, Adiponectin, Cardiovascular Diseases/genetics*, Adult, Lipid Peroxides, Nonesterified/blood, Adiponectin/genetics*, Genotype, Lipoproteins, 610, Lipid Peroxides/metabolism, Humans, Particle Size, Polymorphism, Korea, Blood Glucose/metabolism, Lipids/blood, C-Reactive Protein/metabolism, Body Weight, Adipose Tissue/physiology*, Cardiovascular Diseases/epidemiology*, Body Height, Body Weight/physiology, Malondialdehyde/metabolism, Insulin Resistance
citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).52 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Average influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Top 10% impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 10%
Citations provided by BIP!Popularity provided by BIP!