Role of NF-κB-Dependent Signaling in the Growth Capacity of Mesenchymal Progenitor Cells Under the Influence of Basic Fibroblast Growth Factor
pmid: 25065316
Role of NF-κB-Dependent Signaling in the Growth Capacity of Mesenchymal Progenitor Cells Under the Influence of Basic Fibroblast Growth Factor
We studied the in vitro role of NF-κB-dependent signaling in the growth capacity of mesenchymal progenitor cells upon stimulation by basic fibroblast growth factor. Proliferative activity of progenitor cells was suppressed by specifi c inhibitors of this transcription factor (NF-κB), oridonin and aurothiomalate. These inhibitors had no effect on differentiation of fibroblast CFU.
Mice, Inbred CBA, NF-kappa B, Animals, Fibroblast Growth Factor 2, Mesenchymal Stem Cells, Cell Cycle Checkpoints, Second Messenger Systems, Cells, Cultured, Cell Proliferation
Mice, Inbred CBA, NF-kappa B, Animals, Fibroblast Growth Factor 2, Mesenchymal Stem Cells, Cell Cycle Checkpoints, Second Messenger Systems, Cells, Cultured, Cell Proliferation
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