Tenascin-C is an innate broad-spectrum, HIV-1–neutralizing protein in breast milk
Copyright policy )Tenascin-C is an innate broad-spectrum, HIV-1–neutralizing protein in breast milk
Significance Achieving an AIDS-free generation will require elimination of breast milk transmission of HIV-1, as breastfeeding is a cornerstone of infant survival in developing regions. Antiretroviral prophylaxis considerably reduces postnatal HIV-1 transmission, yet its efficacy is limited by access, adherence, toxicities, and resistance of maternal HIV-1 strains. Alternative, safe strategies of impeding postnatal HIV-1 transmission will be required to eliminate infant HIV-1 infection. In this paper, we identify an innate HIV-neutralizing protein in breast milk, Tenascin-C, which captures and neutralizes HIV-1 virions via binding to the chemokine coreceptor binding site on the HIV-1 Envelope. This protein has the potential to be developed as a prevention strategy for postnatal and other modes of HIV-1 transmission.
- Duke University Health System United States
- Boston Children's Hospital United States
- Duke University United States
- Duke Medical Center United States
- Duke University Hospital United States
570, Infectious Disease Transmission, Blotting, Western, Mass Spectrometry, Cell Line, Dose-Response Relationship, Inhibitory Concentration 50, Viral Envelope Proteins, Vertical, Humans, Immunoprecipitation, Chromatography, Acquired Immunodeficiency Syndrome, Dose-Response Relationship, Drug, Milk, Human, Blotting, Tenascin, Chromatography, Ion Exchange, Infectious Disease Transmission, Vertical, Ion Exchange, Milk, HIV-1, Female, Drug, Western, Human
570, Infectious Disease Transmission, Blotting, Western, Mass Spectrometry, Cell Line, Dose-Response Relationship, Inhibitory Concentration 50, Viral Envelope Proteins, Vertical, Humans, Immunoprecipitation, Chromatography, Acquired Immunodeficiency Syndrome, Dose-Response Relationship, Drug, Milk, Human, Blotting, Tenascin, Chromatography, Ion Exchange, Infectious Disease Transmission, Vertical, Ion Exchange, Milk, HIV-1, Female, Drug, Western, Human
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