An A/G polymorphism of core 2 branching enzyme gene is associated with prostate cancer
Copyright policy )An A/G polymorphism of core 2 branching enzyme gene is associated with prostate cancer
The expression of core 2 beta1,6-N-acetylglucosaminyltransferase-1 (C2GnT) is associated with development and progression of malignancy. Sequence analysis showed that the codon 152 of C2GnT has a polymorphism having GTT encoding valine or ATT encoding isoleucine. By examining the polymorphism in prostate cancer and benign prostatic hyperplasia patients, we found that the C2GnT G allele was more frequently observed in the prostate cancer group (p=0.015) than the control group. Men with the GG genotype had a 3.60-fold increased risk of prostate cancer, and men with the AG genotype had a 1.58-fold increased risk of prostate cancer compared with those with the AA genotype. The G allele was found to have a gene dosage effect for prostate cancer risk. No such risk was associated for benign prostatic hyperplasia. These results demonstrate that C2GnT A/G polymorphism is associated with the susceptibility to prostate cancer in a Japanese population.
- Akita University Japan
- Hirosaki University Japan
- Sanford Burnham Prebys Medical Discovery Institute United States
Male, Polymorphism, Genetic, Base Sequence, Prostatic Neoplasms, Middle Aged, 1,4-alpha-Glucan Branching Enzyme, Case-Control Studies, Humans, Genetic Predisposition to Disease, Aged, DNA Primers
Male, Polymorphism, Genetic, Base Sequence, Prostatic Neoplasms, Middle Aged, 1,4-alpha-Glucan Branching Enzyme, Case-Control Studies, Humans, Genetic Predisposition to Disease, Aged, DNA Primers
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