A core promoter element downstream of the TATA box that is recognized by TFIIB
Copyright policy )A core promoter element downstream of the TATA box that is recognized by TFIIB
We have defined a core promoter element downstream of the TATA box that is recognized by TFIIB. This involves a DNA-binding domain in TFIIB that is distinct from the helix–turn–helix motif (which recognizes an element upstream of the TATA box). The TFIIB recognition element we describe regulates transcription in a manner that is promoter context-dependent, particularly with respect to the TFIIB recognition element that is located upstream of the TATA box. Thus TFIIB can recognize two distinct sequence elements that flank the TATA box, employing independent DNA-binding motifs and cooperating in the regulation of transcription.
- University of Salford United Kingdom
Cell-Free System, Transcription, Genetic, Promoter, TFIIB, Response Elements, TATA Box, Adenoviridae, Protein Structure, Tertiary, Gene Expression Regulation, Mutagenesis, Site-Directed, Transcription Factor TFIIB, Humans, RNA polymerase II, Transcription, HeLa Cells, Protein Binding
Cell-Free System, Transcription, Genetic, Promoter, TFIIB, Response Elements, TATA Box, Adenoviridae, Protein Structure, Tertiary, Gene Expression Regulation, Mutagenesis, Site-Directed, Transcription Factor TFIIB, Humans, RNA polymerase II, Transcription, HeLa Cells, Protein Binding
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