Genetic alterations of the cohesin complex genes in myeloid malignancies
Copyright policy )Genetic alterations of the cohesin complex genes in myeloid malignancies
Key PointsRecurrent hypomorphic cohesin defects and cohesin low expression were identified in a significant proportion of patients with MDS and AML. Cohesin mutations likely represent secondary events in clonal hierarchy and contribute to clonal transformation.
- Cleveland Clinic United States
- Translational Research in Oncology Canada
- Memorial Sloan Kettering Cancer Center United States
- Cleveland Clinic Lerner Research Institute United States
Male, Myeloproliferative Disorders, Chromosomal Proteins, Non-Histone, Cell Cycle Proteins, Disease-Free Survival, Repressor Proteins, Survival Rate, Leukemia, Myeloid, Acute, Cross-Sectional Studies, Proto-Oncogene Proteins, Core Binding Factor Alpha 2 Subunit, Mutation, Humans, Female, Cohesins, Aged, Genes, Neoplasm
Male, Myeloproliferative Disorders, Chromosomal Proteins, Non-Histone, Cell Cycle Proteins, Disease-Free Survival, Repressor Proteins, Survival Rate, Leukemia, Myeloid, Acute, Cross-Sectional Studies, Proto-Oncogene Proteins, Core Binding Factor Alpha 2 Subunit, Mutation, Humans, Female, Cohesins, Aged, Genes, Neoplasm
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