MFH‐1, a new member of the fork head domain family, is expressed in developing mesenchyme
Copyright policy )MFH‐1, a new member of the fork head domain family, is expressed in developing mesenchyme
We have isolated a novel mouse gene, MFH‐1 (mesenchyme fork head 1) that is related to the Drosophila fork head and rat HNF3 genes. MFH‐1 encodes a distinct fork head domain that is classified into a distinct subfamily. A recombinant MFH‐1 protein could bind to the HNF3 binding site. MFH‐1 is expressed temporally in developing embryos, first in the non‐notochordal mesoderm and later in areas of mesenchymal condensation in the trunk, head, and limbs. Our results suggest that MFH‐1 might be involved in the formation of special mesenchymal tissues.
- Osaka University Japan
Hepatocyte Nuclear Factor 3-alpha, Embryo, Nonmammalian, Molecular Sequence Data, Gene Expression, Development, Kidney, Polymerase Chain Reaction, Mesoderm, Embryonic and Fetal Development, Mice, Fork head domain, Animals, Mesenchyme, Amino Acid Sequence, RNA, Messenger, Brain, Nuclear Proteins, Forkhead Transcription Factors, Embryo, Mammalian, Rats, DNA-Binding Proteins, Hepatocyte Nuclear Factor 3-beta, Drosophila, Hepatocyte Nuclear Factor 3-gamma
Hepatocyte Nuclear Factor 3-alpha, Embryo, Nonmammalian, Molecular Sequence Data, Gene Expression, Development, Kidney, Polymerase Chain Reaction, Mesoderm, Embryonic and Fetal Development, Mice, Fork head domain, Animals, Mesenchyme, Amino Acid Sequence, RNA, Messenger, Brain, Nuclear Proteins, Forkhead Transcription Factors, Embryo, Mammalian, Rats, DNA-Binding Proteins, Hepatocyte Nuclear Factor 3-beta, Drosophila, Hepatocyte Nuclear Factor 3-gamma
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