The Association of GSTM1 Deletion Polymorphism with Lung Cancer Risk in Chinese Population: Evidence from an Updated Meta-analysis
Copyright policy )The Association of GSTM1 Deletion Polymorphism with Lung Cancer Risk in Chinese Population: Evidence from an Updated Meta-analysis
AbstractPrevious studies have reported the association of glutathione S-transferase M1 (GSTM1) deletion polymorphism with genetic susceptibility of lung cancer in Chinese population. However, the results remained controversial. The aim of this study was to clarify the association of GSTM1 deletion polymorphism with lung cancer risk in Chinese population. Systematic searches were performed through the search engines of Medline/Pubmed, Web of Science, EMBASE, CNKI and Wanfang Medical Online. The pooled effects were calculated by STATA 10.0 software package and Review Manager 5.0.24. Overall, we observed an association of GSTM1 deletion polymorphism with increased lung cancer risk in Chinese population (odds ratio (OR) = 1.46, 95% confidence interval (95%CI): 1.32–1.66 for null genotype vs. present genotype) based on 53 studies including 7,833 cases and 10,353 controls. We also observed an increased risk of GSTM1 null genotype for lung cancer in stratified analyses by source of control, smoking status and histological type. The findings suggest that GSTM1 deletion polymorphism may contribute to lung cancer risk in Chinese population. Further, well-designed studies with larger sample sizes are required to verify the results.
- Zhengzhou University China (People's Republic of)
- Henan Provincial Center for Disease Control and Prevention China (People's Republic of)
- Centers for Disease Control and Prevention United States
Male, Lung Neoplasms, Polymorphism, Genetic, Smoking, Gene Expression, Adenocarcinoma, Article, Asian People, Risk Factors, Case-Control Studies, Carcinoma, Squamous Cell, Odds Ratio, Humans, Female, Genetic Predisposition to Disease, Gene Deletion, Glutathione Transferase
Male, Lung Neoplasms, Polymorphism, Genetic, Smoking, Gene Expression, Adenocarcinoma, Article, Asian People, Risk Factors, Case-Control Studies, Carcinoma, Squamous Cell, Odds Ratio, Humans, Female, Genetic Predisposition to Disease, Gene Deletion, Glutathione Transferase
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