Drosophila Tempura, a Novel Protein Prenyltransferase α Subunit, Regulates Notch Signaling Via Rab1 and Rab11
Copyright policy )Drosophila Tempura, a Novel Protein Prenyltransferase α Subunit, Regulates Notch Signaling Via Rab1 and Rab11
Vesicular trafficking plays a key role in tuning the activity of Notch signaling. Here, we describe a novel and conserved Rab geranylgeranyltransferase (RabGGT)-α-like subunit that is required for Notch signaling-mediated lateral inhibition and cell fate determination of external sensory organs. This protein is encoded by tempura, and its loss affects the secretion of Scabrous and Delta, two proteins required for proper Notch signaling. We show that Tempura forms a heretofore uncharacterized RabGGT complex that geranylgeranylates Rab1 and Rab11. This geranylgeranylation is required for their proper subcellular localization. A partial dysfunction of Rab1 affects Scabrous and Delta in the secretory pathway. In addition, a partial loss Rab11 affects trafficking of Delta. In summary, Tempura functions as a new geranylgeranyltransferase that regulates the subcellular localization of Rab1 and Rab11, which in turn regulate trafficking of Scabrous and Delta, thereby affecting Notch signaling.
- Howard Hughes Medical Institute United States
- Baylor College of Medicine United States
- Texas Children's Hospital United States
Receptors, Notch, QH301-705.5, Intracellular Signaling Peptides and Proteins, Protein Prenylation, Membrane Proteins, Dimethylallyltranstransferase, rab1 GTP-Binding Proteins, Protein Subunits, Drosophila melanogaster, Gene Expression Regulation, rab GTP-Binding Proteins, Animals, Drosophila Proteins, Biology (General), Protein Processing, Post-Translational, Research Article, Glycoproteins, Signal Transduction
Receptors, Notch, QH301-705.5, Intracellular Signaling Peptides and Proteins, Protein Prenylation, Membrane Proteins, Dimethylallyltranstransferase, rab1 GTP-Binding Proteins, Protein Subunits, Drosophila melanogaster, Gene Expression Regulation, rab GTP-Binding Proteins, Animals, Drosophila Proteins, Biology (General), Protein Processing, Post-Translational, Research Article, Glycoproteins, Signal Transduction
citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).49 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Top 10% influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Top 10% impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 10%
Citations provided by BIP!Popularity provided by BIP!