A requirement for bone morphogenetic protein-7 during development of the mammalian kidney and eye.
Copyright policy )A requirement for bone morphogenetic protein-7 during development of the mammalian kidney and eye.
BMP-7/OP-1, a member of the transforming growth factor-beta (TGF-beta) family of secreted growth factors, is expressed during mouse embryogenesis in a pattern suggesting potential roles in a variety of inductive tissue interactions. The present study demonstrates that mice lacking BMP-7 display severe defects confined to the developing kidney and eye. Surprisingly, the early inductive tissue interactions responsible for establishing both organs appear largely unaffected. However, the absence of BMP-7 disrupts the subsequent cellular interactions required for their continued growth and development. Consequently, homozygous mutant animals exhibit renal dysplasia and anophthalmia at birth. Overall, these findings identify BMP-7 as an essential signaling molecule during mammalian kidney and eye development.
- University of California, Los Angeles United States
- Harvard University United States
- University of Nebraska Medical Center United States
Base Sequence, Bone Morphogenetic Protein 7, Molecular Sequence Data, Proteins, Inbred C57BL, Eye, Kidney, Medical Cell Biology, Mice, Inbred C57BL, Mice, Transforming Growth Factor beta, Bone Morphogenetic Proteins, Mutation, Medical Anatomy, Animals, Female, Medical Genetics, DNA Primers
Base Sequence, Bone Morphogenetic Protein 7, Molecular Sequence Data, Proteins, Inbred C57BL, Eye, Kidney, Medical Cell Biology, Mice, Inbred C57BL, Mice, Transforming Growth Factor beta, Bone Morphogenetic Proteins, Mutation, Medical Anatomy, Animals, Female, Medical Genetics, DNA Primers
citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).1K popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Top 1% influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Top 0.1% impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 0.1%
Citations provided by BIP!Popularity provided by BIP!