Interleukin 1 receptor antagonist is a member of the interleukin 1 gene family: evolution of a cytokine control mechanism.
Copyright policy )Interleukin 1 receptor antagonist is a member of the interleukin 1 gene family: evolution of a cytokine control mechanism.
Interleukin 1 receptor antagonist (IL-1ra) is a protein that binds to the IL-1 receptor and blocks the binding of both IL-1 alpha and -beta without inducing a signal of its own. Human IL-1ra has some sequence identity to human IL-1 beta, but the evolutionary relationship between these proteins has been unclear. We show that the genes for human, mouse, and rat IL-1ra are similar to the genes for IL-1 alpha and IL-1 beta in intron-exon organization, indicating that gene duplication events were important in the creation of this gene family. Furthermore, an analysis of sequence comparisons and mutation rates for IL-1 alpha, IL-1 beta, and IL-1ra suggests that the duplication giving rise to the IL-1ra gene was an early event in the evolution of the gene family. Comparisons between the mature sequences for IL-1ra, IL-1 alpha, and IL-1 beta suggest that IL-1ra has a beta-stranded structure like to IL-1 alpha and IL-1 beta, consistent with the three proteins being related. The N-terminal sequences of IL-1ra appear to be derived from a region of the genome different than those of IL-1 alpha and IL-1 beta, thus explaining their different modes of biosynthesis and suggesting an explanation for their different biological activities.
Base Sequence, Molecular Sequence Data, Receptors, Interleukin-1, Rats, Inbred Strains, Introns, Rats, Mice, Multigene Family, Sequence Homology, Nucleic Acid, Mutation, Animals, Humans, Amino Acid Sequence, Receptors, Immunologic, Sequence Alignment, Interleukin-1
Base Sequence, Molecular Sequence Data, Receptors, Interleukin-1, Rats, Inbred Strains, Introns, Rats, Mice, Multigene Family, Sequence Homology, Nucleic Acid, Mutation, Animals, Humans, Amino Acid Sequence, Receptors, Immunologic, Sequence Alignment, Interleukin-1
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