The thymosin β4 gene is strongly activated in neural tissues during early postimplantation mouse development
Copyright policy )The thymosin β4 gene is strongly activated in neural tissues during early postimplantation mouse development
We studied the temporal and spatial distribution of the mRNA encoding for thymosin beta 4 (T beta 4), a small acidic actin-sequestering peptide, during the early postimplantation mouse development. Analysis of total embryo RNA demonstrated a strong activation of T beta 4 gene after gastrulation and coincident with neurulation. In situ hybridization showed that T beta 4 mRNA was strongly expressed in the central nervous system and peripheral ganglia, paralleling the gradient of neuronal differentiation. An intense signal was also observed in intraventricular macrophages and blood vessels. The role of T beta 4 in mammalian neuroembryogenesis is discussed.
Neurons, Thymosin, Embryonic and Fetal Development, Mice, Thalamus, Animals, Gene Expression Regulation, Developmental, Cell Differentiation, In Situ Hybridization
Neurons, Thymosin, Embryonic and Fetal Development, Mice, Thalamus, Animals, Gene Expression Regulation, Developmental, Cell Differentiation, In Situ Hybridization
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