Identification, sequence, and expression of caveolin-2 defines a caveolin gene family.
Copyright policy )Identification, sequence, and expression of caveolin-2 defines a caveolin gene family.
Caveolin, a 21- to 24-kDa integral membrane protein, is a principal component of caveolae membranes. Caveolin interacts directly with heterotrimeric guanine nucleotide binding proteins (G proteins) and can functionally regulate their activity. Here, an approximately 20-kDa caveolin-related protein, caveolin-2, was identified through microsequencing of adipocyte-derived caveolin-enriched membranes; caveolin was retermed caveolin-1. Caveolins 1 and 2 are similar in most respects. mRNAs for both caveolin-1 and caveolin-2 are most abundantly expressed in white adipose tissue and are induced during adipocyte differentiation. Caveolin-2 colocalizes with caveolin-1, indicating that caveolin-2 also localizes to caveolae. However, caveolin-1 and caveolin-2 differ in their functional interactions with heterotrimeric G proteins, possibly explaining why caveolin-1 and -2 are coexpressed within a single cell.
- Massachusetts Institute of Technology United States
- Harvard University United States
- Shriners Hospitals for Children - Erie United States
- Whitehead Institute for Biomedical Research United States
Sequence Homology, Amino Acid, Caveolin 1, Molecular Sequence Data, Gene Expression, Membrane Proteins, 3T3 Cells, Caveolins, Mice, GTP-Binding Proteins, Multigene Family, Adipocytes, Animals, Humans, Amino Acid Sequence, RNA, Messenger, Fluorescent Antibody Technique, Indirect, Chickens, Sequence Alignment
Sequence Homology, Amino Acid, Caveolin 1, Molecular Sequence Data, Gene Expression, Membrane Proteins, 3T3 Cells, Caveolins, Mice, GTP-Binding Proteins, Multigene Family, Adipocytes, Animals, Humans, Amino Acid Sequence, RNA, Messenger, Fluorescent Antibody Technique, Indirect, Chickens, Sequence Alignment
citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).560 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Top 1% influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Top 1% impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 0.1%
Citations provided by BIP!Popularity provided by BIP!