X-ray Crystallographic Structure of a Compact Dodecamer from a Peptide Derived from Aβ16–36
Copyright policy )X-ray Crystallographic Structure of a Compact Dodecamer from a Peptide Derived from Aβ16–36
The assembly of the β-amyloid peptide, Aβ, into soluble oligomers is associated with neurodegeneration in Alzheimer's disease. The Aβ oligomers are thought to be composed of β-hairpins. Here, the effect of shifting the residue pairing of the β-hairpins on the structures of the oligomers that form is explored through X-ray crystallography. Three residue pairings were investigated using constrained macrocyclic β-hairpins in which Aβ30-36 is juxtaposed with Aβ17-23, Aβ16-22, and Aβ15-21. The Aβ16-22-Aβ30-36 pairing forms a compact ball-shaped dodecamer composed of fused triangular trimers. This dodecamer may help explain the structures of the trimers and dodecamers formed by full-length Aβ.
- University of California, Irvine United States
- University of California, San Francisco United States
Models, Molecular, Crystallography, Amyloid beta-Peptides, Molecular Structure, X-Rays, Molecular, Crystallography, X-Ray, Peptide Fragments, Models, X-Ray
Models, Molecular, Crystallography, Amyloid beta-Peptides, Molecular Structure, X-Rays, Molecular, Crystallography, X-Ray, Peptide Fragments, Models, X-Ray
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