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Target-templated de novo design of macrocyclic d-/l-peptides: discovery of drug-like inhibitors of PD-1

descriptionPublicationkeyboard_double_arrow_right Article , Other literature type 01 Jan 2021 English Publisher:Royal Society of Chemistry (RSC)Journal:Chemical Science, volume 12, pages 5,164-5,170 (issn: 2041-6520, eissn: 2041-6539, Copyright policy )
Authors: Salvador Guardiola; Monica Varese; Xavier Roig; Macarena Sánchez-Navarro; Jesús García; Ernest Giralt;

doi: 10.1039/d1sc01031j

pmid: 34163753

pmc: PMC8179567

handle: 10261/240085

Target-templated de novo design of macrocyclic d-/l-peptides: discovery of drug-like inhibitors of PD-1

Abstract

In silico design of heterochiral cyclic peptides that bind to a specific surface patch on the target protein (PD-1, in this case) and disrupt protein–protein interactions.

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popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
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influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
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impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
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