Fcf1p and Fcf2p are novel nucleolar Saccharomyces cerevisiae proteins involved in pre-rRNA processing
Copyright policy )Fcf1p and Fcf2p are novel nucleolar Saccharomyces cerevisiae proteins involved in pre-rRNA processing
The uncharacterized Saccharomyces cerevisiae proteins Fcf1 and Fcf2, encoded by the ORFs YDR339c and YLR051c, respectively, were identified in a tandem affinity purification experiment of the known 40S factor Faf1p. Most of the proteins associated with TAP-Faf1p are trans-acting factors involved in pre-rRNA processing and 40S subunit biogenesis, in agreement with the previously observed role of Faf1p in 18S rRNA synthesis. Fcf1p and Fcf2p are both essential and localize to the nucleolus. Depletion of Fcf1p and Fcf2p leads to a decrease in synthesis of the 18S rRNA, resulting in a deficit in 40S ribosomal subunits. Northern analysis indicates inefficient processing of pre-rRNA at the A(0), A(1), and A(2) cleavage sites.
- Polish Academy of Learning Poland
- Kazan Institute of Biochemistry and Biophysics Russian Federation
- Department of Biological Sciences Russian Federation
Saccharomyces cerevisiae Proteins, Sequence Homology, Amino Acid, Molecular Sequence Data, Nuclear Proteins, RNA, Fungal, Saccharomyces cerevisiae, Gene Expression Regulation, Fungal, RNA Precursors, RNA, Ribosomal, 18S, Amino Acid Sequence, RNA Processing, Post-Transcriptional, Cell Nucleolus, Protein Binding
Saccharomyces cerevisiae Proteins, Sequence Homology, Amino Acid, Molecular Sequence Data, Nuclear Proteins, RNA, Fungal, Saccharomyces cerevisiae, Gene Expression Regulation, Fungal, RNA Precursors, RNA, Ribosomal, 18S, Amino Acid Sequence, RNA Processing, Post-Transcriptional, Cell Nucleolus, Protein Binding
citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).22 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Top 10% influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Average impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 10%
Citations provided by BIP!Popularity provided by BIP!