RNA Analysis of Consensus Sequence Splicing Mutations: Implications for the Diagnosis of Wilson Disease
pmid: 19371217
handle: 11588/509343 , 11588/360831 , 11386/3099446 , 11392/2387208 , 11568/133068
RNA Analysis of Consensus Sequence Splicing Mutations: Implications for the Diagnosis of Wilson Disease
Wilson disease (WD) is an autosomal recessive disorder caused by a defective function of the copper-transporting ATP7B protein. This results in progressive copper overload and consequent liver, brain, and kidney damage. Approximately 300 WD-causing mutations have been described to date. Missense mutations are largely prevalent, while splice-site mutations are rarer. Of these, only a minority are detected in splicing consensus sequences. Further, few splicing mutations have been studied at the RNA level. In this study we report the RNA molecular characterization of three consensus splice-site mutations identified by DNA analysis in WD patients. One of them, c.51 + 4 A --> T, resides in the consensus sequence of the donor splice site of intron 1; the second, c. 2121 + 3 A --> G, occurred in position + 3 of intron 7; and the c.2447 + 5 G --> A is localized in the consensus sequence of the donor splice site of intron 9. Analysis revealed predominantly abnormal splicing in the samples carrying mutations compared to the normal controls. These results strongly suggest that consensus sequence splice-site mutations result in disease by interfering with the production of the normal WD protein. Our data contribute to understanding the mutational spectrum that affect splicing and improve our capability in WD diagnosis.
- University Federico II of Naples Italy
- University of Pisa Italy
- University of Ferrara Italy
- Università degli studi di Salerno Italy
Male, Adolescent, RNA Splicing, Mutation, Missense, Genes, Recessive, Introns, Adolescent; Age of Onset; Child; Child, Preschool; Consensus Sequence; Female; Genes, Recessive; Hepatolenticular Degeneration; Humans; Introns; Italy; Male; Mutation, Missense; RNA; Mutation; RNA Splicing; Genetics (clinical), Hepatolenticular Degeneration, Italy, Child, Preschool, Consensus Sequence, Mutation, Humans, RNA, Female, Age of Onset, Child
Male, Adolescent, RNA Splicing, Mutation, Missense, Genes, Recessive, Introns, Adolescent; Age of Onset; Child; Child, Preschool; Consensus Sequence; Female; Genes, Recessive; Hepatolenticular Degeneration; Humans; Introns; Italy; Male; Mutation, Missense; RNA; Mutation; RNA Splicing; Genetics (clinical), Hepatolenticular Degeneration, Italy, Child, Preschool, Consensus Sequence, Mutation, Humans, RNA, Female, Age of Onset, Child
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