The p53 family: guardians of maternal reproduction
Copyright policy )The p53 family: guardians of maternal reproduction
The p53 family of proteins consists of p53, p63 and p73, which are transcription factors that affect both cancer and development. It is now emerging that these proteins also regulate maternal reproduction. Whereas p63 is important for maturation of the egg, p73 ensures normal mitosis in the developing blastocyst. p53 subsequently regulates implantation of the embryo through transcriptional control of leukaemia inhibitory factor. Elucidating the cell biological basis of how these factors regulate female fertility may lead to new approaches to the control of human maternal reproduction.
- Inserm France
- University of Rome Tor Vergata Italy
- Harvard University United States
- University Health Network Canada
- French Institute of Health and Medical Research France
Male, Oocyte, Transcription Factor, DNA-Binding Protein, Knockout, Models, Biological, Mice, Models, Animals, Humans, Settore BIO/10 - BIOCHIMICA, Nuclear Protein, Mice, Knockout, Animal, Animals; Blastocyst; DNA-Binding Proteins; Female; Fertility; Humans; Male; Mice; Mice, Knockout; Models, Biological; Nuclear Proteins; Oocytes; Phosphoproteins; Reproduction; Trans-Activators; Transcription Factors; Tumor Suppressor Protein p53; Tumor Suppressor Proteins, Reproduction, Tumor Suppressor Proteins, Nuclear Proteins, Tumor Protein p73, Biological, Phosphoproteins, DNA-Binding Proteins, Blastocyst, Fertility, Trans-Activator, Phosphoprotein, Oocytes, Trans-Activators, Female, Tumor Suppressor Protein p53, Human, Transcription Factors
Male, Oocyte, Transcription Factor, DNA-Binding Protein, Knockout, Models, Biological, Mice, Models, Animals, Humans, Settore BIO/10 - BIOCHIMICA, Nuclear Protein, Mice, Knockout, Animal, Animals; Blastocyst; DNA-Binding Proteins; Female; Fertility; Humans; Male; Mice; Mice, Knockout; Models, Biological; Nuclear Proteins; Oocytes; Phosphoproteins; Reproduction; Trans-Activators; Transcription Factors; Tumor Suppressor Protein p53; Tumor Suppressor Proteins, Reproduction, Tumor Suppressor Proteins, Nuclear Proteins, Tumor Protein p73, Biological, Phosphoproteins, DNA-Binding Proteins, Blastocyst, Fertility, Trans-Activator, Phosphoprotein, Oocytes, Trans-Activators, Female, Tumor Suppressor Protein p53, Human, Transcription Factors
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