Characterization and chromosome location of the mouse link protein gene <i>(Crtl1)</i>
Copyright policy )Characterization and chromosome location of the mouse link protein gene <i>(Crtl1)</i>
Link protein (LP) plays an essential role in endochondral bone formation by stabilizing the supramolecular assemblies of aggrecan and hyaluronan. We have isolated and characterized the mouse link protein gene (<i>Crtl1</i>). It is longer than 40 kb and transcribed from two alternative promoters, leading to heterogenous mRNAs between 5.3 and 1.3 kb in size. Apart from the coding sequence, the 5′ flanking region is also highly conserved in mammals. Immunostaining revealed high levels of LP expression in the cartilaginous primordia of skeletal elements and low levels in other tissues. Using single-strand conformation polymorphism analysis, <i>Crtl1</i> was assigned to mouse chromosome 13, tightly linked to <i>Dhfr.</i>
- Harvard University United States
- City Of Hope National Medical Center United States
- Hungarian Academy of Sciences Hungary
- MTA Biological Research Centre Hungary
- Institute of Biochemistry Hungary
Extracellular Matrix Proteins, Base Sequence, Genetic Linkage, Blotting, Western, Molecular Sequence Data, Chromosome Mapping, Gene Expression Regulation, Developmental, Proteins, Exons, Embryo, Mammalian, Introns, Mice, Animals, Humans, Amino Acid Sequence, Cloning, Molecular, Promoter Regions, Genetic, Conserved Sequence, Polymorphism, Single-Stranded Conformational, Microsatellite Repeats
Extracellular Matrix Proteins, Base Sequence, Genetic Linkage, Blotting, Western, Molecular Sequence Data, Chromosome Mapping, Gene Expression Regulation, Developmental, Proteins, Exons, Embryo, Mammalian, Introns, Mice, Animals, Humans, Amino Acid Sequence, Cloning, Molecular, Promoter Regions, Genetic, Conserved Sequence, Polymorphism, Single-Stranded Conformational, Microsatellite Repeats
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