RNA polymerase III interferes with Ty3 integration
Copyright policy )RNA polymerase III interferes with Ty3 integration
Ty3, a gypsylike retrotransposon of budding yeast, integrates at the transcription initiation site of genes transcribed by RNA polymerase III (pol III). It was previously shown that integration in vitro requires intact promoter elements and the pol III transcription factors TFIIIB and TFIIIC. In order to test the effect of pol III on integration, increasing amounts of a pol III‐containing fraction were added to Ty3 in vitro integration reactions. The pol III‐containing fraction was inhibitory to integration. These results are consistent with a model where the Ty3 integration complex and pol III recognize similar features of the stable transcription complex and compete with each other for access to the transcription initiation site.
- Washington State University United States
- University of California System United States
- University of Mary United States
- University of California, Irvine United States
- UNIVERSITY OF CALIFORNIA IRVINE
Biochemistry & Molecular Biology, RNA polymerase III, tRNA gene, Retroelements, Transcription, Genetic, Virus Integration, Integration, integration, Saccharomyces cerevisiae, Transposable element, Medicinal and Biomolecular Chemistry, Genetic, RNA, Transfer, Genetics, Evolutionary Biology, Ty3, Retrovirus, RNA Polymerase III, RNA-Binding Proteins, transposable element, Transfer, retrovirus, RNA, Biochemistry and Cell Biology, Transcription
Biochemistry & Molecular Biology, RNA polymerase III, tRNA gene, Retroelements, Transcription, Genetic, Virus Integration, Integration, integration, Saccharomyces cerevisiae, Transposable element, Medicinal and Biomolecular Chemistry, Genetic, RNA, Transfer, Genetics, Evolutionary Biology, Ty3, Retrovirus, RNA Polymerase III, RNA-Binding Proteins, transposable element, Transfer, retrovirus, RNA, Biochemistry and Cell Biology, Transcription
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