Transient Catabolic State with Reduced IGF-I after Antenatal Glucocorticoids
Copyright policy )Transient Catabolic State with Reduced IGF-I after Antenatal Glucocorticoids
Glucocorticoid (GC) administration before preterm birth reduces neonatal morbidity but may restrain growth. Here we explored the effect of antenatal GC on nutrient substrates [glucose, FFA, amino acids (AA)], and on IGF-I and IGF-binding protein-1 (IGFBP-1). We analyzed umbilical vein (UV) plasma obtained at birth from 91 preterm newborns that received one course of GC (last exposure 1-1358 h before birth) and 49 newborns that did not. We found that recent GC exposure (-48 h) raised glucose, FFA, and AA concentrations, and the homeostasis model assessment of insulin resistance (HOMA-IR) index, but lowered IGF-I concentrations. The AA surge was greater in newborns with a birth weight z score 0. Although all AA were transiently increased, the increment was most robust for glutamine and alanine. Shorter duration since GC administration and lower IGF-I concentrations independently predicted AA levels. In conclusion, an antenatal course of GC elicited a transient catabolic state encompassing all nutrient substrates, and a temporary drop in IGF-I concentrations. These changes may explain the growth-inhibitory effects of repeated antenatal GC administration. Future research should clarify the role of IGF-I in the protein-catabolic response to GC.
- KU Leuven Belgium
- Katholieke Universiteit Leuven Belgium
Blood Glucose, Male, insulin, fetal-growth, PLASMA-CONCENTRATIONS, ovine fetus, Fatty Acids, Nonesterified, CONTROLLED-TRIAL, c-peptide, Pediatrics, C-PEPTIDE, 1117 Public Health and Health Services, growth-factor-i, Fetus, Pregnancy, plasma-concentrations, GROWTH-FACTOR-I, Birth Weight, Homeostasis, Humans, PHYSIOLOGICAL HYPERCORTISOLEMIA, Amino Acids, Insulin-Like Growth Factor I, Glucocorticoids, physiological hypercortisolemia, Science & Technology, Infant, Newborn, Fetal Blood, human serum, INSULIN, 3213 Paediatrics, FACTOR-BINDING PROTEIN-1, Insulin-Like Growth Factor Binding Protein 1, controlled-trial, FETAL-GROWTH, 1114 Paediatrics and Reproductive Medicine, Premature Birth, Female, factor-binding protein-1, OVINE FETUS, HUMAN SERUM, Life Sciences & Biomedicine
Blood Glucose, Male, insulin, fetal-growth, PLASMA-CONCENTRATIONS, ovine fetus, Fatty Acids, Nonesterified, CONTROLLED-TRIAL, c-peptide, Pediatrics, C-PEPTIDE, 1117 Public Health and Health Services, growth-factor-i, Fetus, Pregnancy, plasma-concentrations, GROWTH-FACTOR-I, Birth Weight, Homeostasis, Humans, PHYSIOLOGICAL HYPERCORTISOLEMIA, Amino Acids, Insulin-Like Growth Factor I, Glucocorticoids, physiological hypercortisolemia, Science & Technology, Infant, Newborn, Fetal Blood, human serum, INSULIN, 3213 Paediatrics, FACTOR-BINDING PROTEIN-1, Insulin-Like Growth Factor Binding Protein 1, controlled-trial, FETAL-GROWTH, 1114 Paediatrics and Reproductive Medicine, Premature Birth, Female, factor-binding protein-1, OVINE FETUS, HUMAN SERUM, Life Sciences & Biomedicine
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