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The DUBm subunit Sgf11 is required for mRNA export and interacts with Cbp80 in Drosophila

descriptionPublicationkeyboard_double_arrow_right Article , Other literature type 18 Sep 2012 English Publisher:Oxford University Press (OUP)Journal:Nucleic Acids Research, volume 40, pages 10,689-10,700 (issn: 0305-1048, eissn: 1362-4962,

Authors: Sofia G. Georgieva; Dmitriy Ya. Gurskiy; Yulii V. Shidlovskii; D. V. Kopytova; A. N. Krasnov; Nadezhda E. Vorobyeva; A. V. Orlova; +1 Authors

doi: 10.1093/nar/gks857

pmid: 22989713

pmc: PMC3510517

The DUBm subunit Sgf11 is required for mRNA export and interacts with Cbp80 in Drosophila

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Abstract

SAGA/TFTC is a histone acetyltransferase complex that has a second enzymatic activity because of the presence of a deubiquitination module (DUBm). Drosophila DUBm consists of Sgf11, ENY2 and Nonstop proteins. We show that Sgf11 has other DUBm-independent functions. It associates with Cbp80 component of the cap-binding complex and is thereby recruited onto growing messenger ribonucleic acid (mRNA); it also interacts with the AMEX mRNA export complex and is essential for hsp70 mRNA export, as well as for general mRNA export from the nucleus. Thus, Sgf11 functions as a component of both SAGA DUBm and the mRNA biogenesis machinery.

Related Organizations

Russian Academy of Sciences
Russian Federation
Institute of Gene Biology
Russian Federation

Keywords

Cell Nucleus, Transcriptional Activation, Cytoplasm, Nucleocytoplasmic Transport Proteins, Embryo, Nonmammalian, Gene Regulation, Chromatin and Epigenetics, RNA Transport, Protein Subunits, Gene Knockdown Techniques, Animals, Drosophila Proteins, Drosophila, HSP70 Heat-Shock Proteins, RNA, Messenger, Promoter Regions, Genetic, Heat-Shock Response, Nuclear Cap-Binding Protein Complex, Histone Acetyltransferases, Transcription Factors

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20 Research products, page 1 of 2

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	citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	29
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