Increased CD4+ T Cell Co-Inhibitory Immune Receptor CEACAM1 in Neonatal Sepsis and Soluble-CEACAM1 in Meningococcal Sepsis: A Role in Sepsis-Associated Immune Suppression?
Copyright policy )Increased CD4+ T Cell Co-Inhibitory Immune Receptor CEACAM1 in Neonatal Sepsis and Soluble-CEACAM1 in Meningococcal Sepsis: A Role in Sepsis-Associated Immune Suppression?
The co-inhibitory immune receptor carcinoembryonic antigen-related cell-adhesion molecule 1 (CEACAM1) and its self-ligand CEACAM1 can suppress T cell function. Suppression of T cell function in sepsis is well documented. Late-onset neonatal sepsis in VLBW-infants was associated with an increased percentage CEACAM1 positive CD4(+) T-cells. Meningococcal septic shock in children was associated with increased serum soluble CEACAM1. In conclusion our data demonstrate increased surface expression of the co-inhibitory immune receptor CEACAM1 in late-onset neonatal sepsis in VLBW-infants, and increased circulating soluble CEACAM1 in children with meningococcal sepsis. Increased T-cell CEACAM1 expression and increased circulating soluble CEACAM1 may contribute to sepsis-associated immune suppression.
- Amsterdam UMC, location VUmc Netherlands
- Radboud University Nijmegen Netherlands
- Erasmus University Rotterdam Netherlands
- Amsterdam UMC Netherlands
- Amsterdam University Medical Centers Netherlands
EMC MM-04-54-08-A, CD4-Positive T-Lymphocytes, Male, EMC OR-02-54-06, Adolescent, Science, N4i 1: Pathogenesis and modulation of inflammation, Antigens, CD, Sepsis, Immune Tolerance, Humans, Child, Q, R, Infant, Newborn, Infant, Infant, Low Birth Weight, Meningococcal Infections, Gene Expression Regulation, Solubility, Child, Preschool, Medicine, Female, Cell Adhesion Molecules, Research Article
EMC MM-04-54-08-A, CD4-Positive T-Lymphocytes, Male, EMC OR-02-54-06, Adolescent, Science, N4i 1: Pathogenesis and modulation of inflammation, Antigens, CD, Sepsis, Immune Tolerance, Humans, Child, Q, R, Infant, Newborn, Infant, Infant, Low Birth Weight, Meningococcal Infections, Gene Expression Regulation, Solubility, Child, Preschool, Medicine, Female, Cell Adhesion Molecules, Research Article
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