HLA-DRB Alleles and Systemic Lupus Erythematosus in Jamaicans
Copyright policy )HLA-DRB Alleles and Systemic Lupus Erythematosus in Jamaicans
The human leukocyte antigens (HLA) are associated with susceptibility to systemic lupus erythematosus (SLE) and manifestations of SLE in different ethnic groups.A DNA-based HLA-typing method was used to determine alleles of HLA-DRB1, DRB3, DRB4 and DRB5 in Jamaican patients. A total of 70 patients and 100 control subjects were studied.HLA-DRB3*01/03 was significantly associated with susceptibility to SLE, while DRB1*15/16 was associated with the presence of oral ulcers in patients with SLE. The haplotype DRB1*13/14.DRB3*01/03 was also more frequent in SLE patients. No other significant associations were found.The SLE HLA associations in Jamaicans differ from those in other black populations.
- University of the West Indies System Jamaica
- University of the West Indies Jamaica
Adult, Male, Jamaica, Adolescent, HLA-DR Antigens, Middle Aged, HLA-DRB5 Chains, Humans, Lupus Erythematosus, Systemic, Female, Disease Susceptibility, HLA-DRB3 Chains, HLA-DRB4 Chains, Aged, HLA-DRB1 Chains
Adult, Male, Jamaica, Adolescent, HLA-DR Antigens, Middle Aged, HLA-DRB5 Chains, Humans, Lupus Erythematosus, Systemic, Female, Disease Susceptibility, HLA-DRB3 Chains, HLA-DRB4 Chains, Aged, HLA-DRB1 Chains
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