Differential role of CD97 in interleukin-8-induced and granulocyte-colony stimulating factor-induced hematopoietic stem and progenitor cell mobilization
Copyright policy )Differential role of CD97 in interleukin-8-induced and granulocyte-colony stimulating factor-induced hematopoietic stem and progenitor cell mobilization
CD97 is broadly expressed on hematopoietic cells and is involved in neutrophil migration. Since neutrophils are key regulators in HSC/HPC mobilization, we studied a possible role for CD97 in interleukin-8 and granulocyte-colony stimulating factor-induced HSC/HPC mobilization. Mobilization was absent in mice receiving CD97 mAb followed by interleukin-8, while granulocyte-colony stimulating factor-induced mobilization remained unaltered following anti-CD97 administration. Furthermore, combined administration of CD97 mAb and IL-8 induced a significant reduction in the neutrophilic compartment. We hypothesize that the absence of interleukin-8-induced HSC/HPC mobilization after CD97 mAb administration is due to its effect on neutrophil function.
- Amsterdam UMC Netherlands
- University of Amsterdam Netherlands
- UNIVERSITEIT VAN AMSTERDAM Netherlands
- Amsterdam UMC, location AMC Netherlands
- Academic Medical Center - University of Amsterdam Netherlands
Male, Mice, Inbred BALB C, Membrane Glycoproteins, Neutrophils, Recombinant Fusion Proteins, Interleukin-8, Antibodies, Monoclonal, Drug Administration Schedule, Hematopoietic Stem Cell Mobilization, Receptors, G-Protein-Coupled, Colony-Forming Units Assay, Chemotaxis, Leukocyte, Leukocyte Count, Mice, Granulocyte Colony-Stimulating Factor, Animals, Diseases of the blood and blood-forming organs, RC633-647.5
Male, Mice, Inbred BALB C, Membrane Glycoproteins, Neutrophils, Recombinant Fusion Proteins, Interleukin-8, Antibodies, Monoclonal, Drug Administration Schedule, Hematopoietic Stem Cell Mobilization, Receptors, G-Protein-Coupled, Colony-Forming Units Assay, Chemotaxis, Leukocyte, Leukocyte Count, Mice, Granulocyte Colony-Stimulating Factor, Animals, Diseases of the blood and blood-forming organs, RC633-647.5
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