The CELSR1 polymorphisms rs6007897 and rs4044210 are associated with ischaemic stroke in Chinese Han population
Copyright policy )The CELSR1 polymorphisms rs6007897 and rs4044210 are associated with ischaemic stroke in Chinese Han population
Background: Recently, CELSR1 was identified by genome-wide association studies (GWAS) as a susceptibility gene for ischaemic stroke (IS) in Japanese individuals. Aim: The goal was to examine whether CELSR1 variants are associated with IS in the Chinese Han population. Subjects and methods: This study genotyped two single nucleotide polymorphisms (SNPs) of CELSR1, rs6007897 and rs4044210, in a Chinese sample of 569 IS cases and 581 controls and assessed their genotype and allele associations with IS. Results: The results showed that rs6007897 and rs4044210 variants of CELSR1 were significantly (p p Conclusion: Taken together, the present study has proven for the first time that CELSR1 is a susceptibility gene for IS in the Chinese Han population, especially for LAA.
- Fujian Medical University China (People's Republic of)
- Xiamen University China (People's Republic of)
- First Affiliated Hospital of Xiamen University China (People's Republic of)
Male, China, Middle Aged, Atherosclerosis, Cadherins, Polymorphism, Single Nucleotide, Brain Ischemia, Stroke, Case-Control Studies, Ethnicity, Humans, Female, Genetic Predisposition to Disease, Aged
Male, China, Middle Aged, Atherosclerosis, Cadherins, Polymorphism, Single Nucleotide, Brain Ischemia, Stroke, Case-Control Studies, Ethnicity, Humans, Female, Genetic Predisposition to Disease, Aged
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