dEHBP1 controls exocytosis and recycling of Delta during asymmetric divisions
Copyright policy )dEHBP1 controls exocytosis and recycling of Delta during asymmetric divisions
Notch signaling governs binary cell fate determination in asymmetrically dividing cells. Through a forward genetic screen we identified the fly homologue of Eps15 homology domain containing protein-binding protein 1 (dEHBP1) as a novel regulator of Notch signaling in asymmetrically dividing cells. dEHBP1 is enriched basally and at the actin-rich interface of pII cells of the external mechanosensory organs, where Notch signaling occurs. Loss of function of dEHBP1 leads to up-regulation of Sanpodo, a regulator of Notch signaling, and aberrant trafficking of the Notch ligand, Delta. Furthermore, Sec15 and Rab11, which have been previously shown to regulate the localization of Delta, physically interact with dEHBP1. We propose that dEHBP1 functions as an adaptor molecule for the exocytosis and recycling of Delta, thereby affecting cell fate decisions in asymmetrically dividing cells.
- Baylor College of Medicine United States
- Fox Chase Cancer Center United States
- BAYLOR COLLEGE OF MEDICINE
- Howard Hughes Medical Institute United States
- Temple University Health System United States
Receptors, Notch, Asymmetric Cell Division, Microfilament Proteins, Intracellular Signaling Peptides and Proteins, Vesicular Transport Proteins, Membrane Proteins, Exocytosis, Gene Expression Regulation, rab GTP-Binding Proteins, Animals, Drosophila Proteins, Drosophila, Research Articles, Adaptor Proteins, Signal Transducing, Signal Transduction
Receptors, Notch, Asymmetric Cell Division, Microfilament Proteins, Intracellular Signaling Peptides and Proteins, Vesicular Transport Proteins, Membrane Proteins, Exocytosis, Gene Expression Regulation, rab GTP-Binding Proteins, Animals, Drosophila Proteins, Drosophila, Research Articles, Adaptor Proteins, Signal Transducing, Signal Transduction
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