Polymorphism in cathelicidin gene (CAMP) that alters Hypoxia‐inducible factor (HIF‐1α::ARNT) binding is not associated with tuberculosis
Copyright policy )Polymorphism in cathelicidin gene (CAMP) that alters Hypoxia‐inducible factor (HIF‐1α::ARNT) binding is not associated with tuberculosis
SummaryPolymorphisms in the CAMP gene (cathelicidin) have not been tested in tuberculosis susceptibility. We tested polymorphisms rs9844812 (HIF‐1α::ARNT binding site) and rs56122065 (CAMP) plus rs1800972 (DEFB1). SNP rs1800972 was associated with extrapulmonary tuberculosis (EPTB) in a codominant model (genotype CG, P = 0.037, OR 4.82; 95% CI: 0.92–47.42; statistical power, 82%), but not PTB (P = 0.101) in a Mexican population.
Binding Sites, Polymorphism, Genetic, Base Sequence, Genotype, Aryl Hydrocarbon Receptor Nuclear Translocator, Molecular Sequence Data, Exons, Hypoxia-Inducible Factor 1, alpha Subunit, Polymorphism, Single Nucleotide, Gene Frequency, Case-Control Studies, Humans, Position-Specific Scoring Matrices, Genetic Predisposition to Disease, Amino Acid Sequence, Nucleotide Motifs, 5' Untranslated Regions, Promoter Regions, Genetic, Alleles, Antimicrobial Cationic Peptides
Binding Sites, Polymorphism, Genetic, Base Sequence, Genotype, Aryl Hydrocarbon Receptor Nuclear Translocator, Molecular Sequence Data, Exons, Hypoxia-Inducible Factor 1, alpha Subunit, Polymorphism, Single Nucleotide, Gene Frequency, Case-Control Studies, Humans, Position-Specific Scoring Matrices, Genetic Predisposition to Disease, Amino Acid Sequence, Nucleotide Motifs, 5' Untranslated Regions, Promoter Regions, Genetic, Alleles, Antimicrobial Cationic Peptides
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