CR3 (CD11b/CD18) and CR4 (CD11c/CD18) Are Involved in Complement-Independent Antibody-Mediated Phagocytosis of Cryptococcus neoformans
Copyright policy )CR3 (CD11b/CD18) and CR4 (CD11c/CD18) Are Involved in Complement-Independent Antibody-Mediated Phagocytosis of Cryptococcus neoformans
IgM and IgA to the Cryptococcus neoformans capsular glucuronoxylomannan (GXM) promote complement-independent phagocytosis by macrophages with efficiency comparable to that of IgG1. IgM- and IgA-mediated phagocytosis of C. neoformans was proportional to CR3 expression, inhibited by Abs to CR3 (CD11b/CD18) and CR4 (CD11c/CD18), and dramatically reduced with macrophages of CD18-deficient mice. IgM and IgA promoted ingestion of yeast cells by CHO cells expressing CR3 and CR4. In contrast, IgG1-mediated phagocytosis was only partially inhibited by Abs to CR3 and CR4. Phagocytosis by IgM and IgA but not IgG1 was inhibited by soluble GXM, which binds CD18. Involvement of CR in antibody-mediated complement-independent phagocytosis indicates a new link between innate and adaptive immune systems.
- Albert Einstein College of Medicine United States
Immunology, Integrin alphaXbeta2, Macrophage-1 Antigen, CHO Cells, Cell Line, Mice, Phagocytosis, Polysaccharides, Cricetinae, Lectins, Immunology and Allergy, Animals, Complement Activation, Mice, Knockout, Macrophages, Monosaccharides, Lymphocyte Function-Associated Antigen-1, Immunoglobulin A, Kinetics, Infectious Diseases, Immunoglobulin M, CD18 Antigens, Cryptococcus neoformans
Immunology, Integrin alphaXbeta2, Macrophage-1 Antigen, CHO Cells, Cell Line, Mice, Phagocytosis, Polysaccharides, Cricetinae, Lectins, Immunology and Allergy, Animals, Complement Activation, Mice, Knockout, Macrophages, Monosaccharides, Lymphocyte Function-Associated Antigen-1, Immunoglobulin A, Kinetics, Infectious Diseases, Immunoglobulin M, CD18 Antigens, Cryptococcus neoformans
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