Association analysis of the 5‐HT6 receptor polymorphism C267T with depression in patients with Alzheimer's disease
Copyright policy )Association analysis of the 5‐HT6 receptor polymorphism C267T with depression in patients with Alzheimer's disease
Abstract A significant increase of 267C allele of the 5‐HT6 receptor gene has been reported in patients with Alzheimer's disease (AD). Because a deficit in serotonergic neurotransmission is involved in major depression, we tried to find out whether 267C allele is associated with depressive disorders in AD. A psychiatrist interviewed all AD patients and their caregivers for evidence of depression using a Chinese version of the Standard Clinical Interview for DSM‐III‐R. The difference in the 5‐HT6 genotype or allele distributions between the AD patients with depressive disorders (n = 25) and those without (n = 120) was not significant.
- Chang Gung University Taiwan
- National Yang Ming University Taiwan
- The Neurological Institute United States
- Linkou Chang Gung Memorial Hospital Taiwan
- Taipei Veterans General Hospital Taiwan
Aged, 80 and over, Male, Depressive Disorder, Polymorphism, Genetic, Genotype, Taiwan, Severity of Illness Index, Alzheimer Disease, Case-Control Studies, Receptors, Serotonin, Humans, Alleles, Polymorphism, Restriction Fragment Length, Aged
Aged, 80 and over, Male, Depressive Disorder, Polymorphism, Genetic, Genotype, Taiwan, Severity of Illness Index, Alzheimer Disease, Case-Control Studies, Receptors, Serotonin, Humans, Alleles, Polymorphism, Restriction Fragment Length, Aged
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