An investigation into the role of P-glycoprotein in Alzheimer's disease lesion pathogenesis
Copyright policy )An investigation into the role of P-glycoprotein in Alzheimer's disease lesion pathogenesis
The pathogenesis of Alzheimer's disease (AD) senile plaque (SP) and neurofibrillary tangle (NFT) lesions putatively involves a compromised blood-brain barrier (BBB). P-glycoprotein (P-gp) is a recognized BBB-related efflux transporter protein. In this investigation we determined the density of SP and NFT lesions and capillary densities stained positively for P-glycoprotein (P-gp), and other transport proteins, in AD and control group (CG) brain samples. Our results indicate that there are significant negative correlations (p<.01) between the densities of NFT and SP(40) lesions and P-gp positive capillaries in AD but not CG brain samples. Significant positive correlations (p<.01) were observed between the densities of P-gp positive capillaries and LRP and RAGE positive capillaries in both AD and CG brains. These results also suggest that the levels of capillary P-gp may contribute to AD lesion development and that the role of P-gp is associated with that of LRP and RAGE.
- McMaster University Canada
- Brock University Canada
- Hamilton Health Sciences Canada
Adult, Aged, 80 and over, Male, Receptor for Advanced Glycation End Products, Neurofibrillary Tangles, Plaque, Amyloid, Middle Aged, Immunohistochemistry, Capillaries, Alzheimer Disease, Blood-Brain Barrier, Humans, Female, ATP Binding Cassette Transporter, Subfamily B, Member 1, Receptors, Immunologic, Low Density Lipoprotein Receptor-Related Protein-1, Aged
Adult, Aged, 80 and over, Male, Receptor for Advanced Glycation End Products, Neurofibrillary Tangles, Plaque, Amyloid, Middle Aged, Immunohistochemistry, Capillaries, Alzheimer Disease, Blood-Brain Barrier, Humans, Female, ATP Binding Cassette Transporter, Subfamily B, Member 1, Receptors, Immunologic, Low Density Lipoprotein Receptor-Related Protein-1, Aged
citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).58 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Top 10% influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Top 10% impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 10%
Citations provided by BIP!Popularity provided by BIP!